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Zinc and sperm motility

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Our investigation showed that Zn contained many unique properties in human, especially males. The antioxidant quality is one of them. Also, the increased reactive oxygen species levels in the seminal plasma of men who are both infertile and smokers Zinc and sperm motility the Zn content of seminal plasma in a way that physiology of spermatozoa can be affected as well.

Moreover, Zn acts as a toxic repercussionagainst heavy metals and cigarette inflammatory agents. It plays a role in epithelial integrity, showing that Zn is essential for maintaining the lining of the reproductive organs and may have a regulative role in the progress of capacitation and acrosome reaction.

In contrast, Zn deficiency impedes spermatogenesis and is a Zinc and sperm motility for sperm abnormalities and has a negative effect on serum testosterone concentration. Based on these findings, Zn microelement is very essential for male fertility. It could be considered as a nutrient marker with many potentials in prevention, diagnosis, and treatment of male infertility. Sexual accessory glands secrete in the seminal plasma containing some elements that protect spermatozoa at the time of ejaculation 1.

Zn is a plentiful microelement in the body and it is found in nuts, legumes 3seafood e. Oystersfortified cereals, cremini mushrooms, low-fat yogurt 4 and animal proteins, such as meat, fish and milk. Some reports showed that consumption Zinc and sperm motility these natural foods can enhance germinal cell proliferation 5and poor Zn nutrition may be an important risk factor for the low quality of sperm and idiopathic male infertility 6.

Dietary Zn deficiency less than 5 ppm impairs reproduction in males and females. Zn has many important functions in the spermatozoa physiology, including effects on lipid flexibility and sperm membrane stabilization It also has a regulated role in capacitation and the acrosome reaction of sperm and is essential for Zinc and sperm motility and embryonic implantation Proteins containing Zn and selenium in mammalian spermatozoa are involved in modulating the amount of reactive oxygen species ROS ; therefore, it is interesting to investigate whether balanced amounts of Zn and other oligoelements that are added to the semen diluent would moderate the deleterious effects of ROS on chromatin structure In our previous study, it was demonstrated that an important risk factor for low quality of sperm and idiopathic male infertility is poor Zn nutrition 6.

But in this review, the focus was on the various roles of Zn in male health, reproductive system, quality and function of sperm, as well as the effects of Zinc and sperm motility factors on Zn and finally the molecular and cellular mechanisms of Zn.

The nearby organs include prostate, liver, the gastrointestinal tract; kidney, skin, lung, adrenals, brain, heart, eyes and pancreas contain estimable concentrations of Zn. Blood tests for Zn deficiency are inaccurate because majority of Zn is cumulative inside cells and is not free in the blood.

Assisting immune function, patronage of healthy cell growth, having a role in preserving prostate health, sexual health and testosterone hormone levels are typical examples. It has been demonstrated that Zn plays a significant role in reproductive functions 14 Hosseinzadeh Colager et al.

The level of Zn in fertile men was There are many reports that showed reduction or increase in consumption of Zn which let to overindulge vis-a-vis deficiency damages in many of the human organs Table 1. For example, Zn deficiency is correlated with reduction in testis volume, a decrease in testicular weight, hypogonadism, gonadal dysfunction, inadequate development of secondary sex specifications in human, shrinkage of seminiferous tubules, the failure of spermatogenesis, male gonad growth and hypogonadism 8.

And so, there are many reports for Zn-physiological roles in human Table 2including its role in gonads- and some enzyme-functions, treatments of some diseases, and better function of apoptosis and immune systems.

Some of these Zn-physiological roles are indicated below. Zn contains many roles in the immune systems Table 3. Zn has a role in almost all aspects of inherent immunity and compatibility, so Zn deficiency may influence weakening of immune system and reproductive system. Zn is effective in various mechanisms, including DNA replication, RNA transcription, proliferation, and differentiation and activation of immune cells in many organs of the body 910 The innate as well as the specific parts of the immune system are influenced by Zn.

The effects of Zn are multifaceted. Zn can induce adhesion of myelomonocytic cells to the endothelium, while Zn chelation diminishes cell recruitment. Thus, Zn is essential, even in the earliest stages of an immune response. At the molecular level, Zn is required for the interaction between the p58 killer cell inhibitory receptor on NK cells and major histocompatibility complex MHC class I molecules, mainly human leukocyte antigen C, on target cells, resulting in the inhibition of the killing activity 8.

Interestingly, Zn is needed to maintain the normal function of natural killer cells, and Zn deficiency may result in non-specific killing activity and functional loss. In addition to effects of upstream signaling molecules, Zn influences gene expression by structural stabilization and functional regulation of various immunological-relevant transcription factors as summarized earlier Zn corrects these adverse effects of cadmium on the immune system and biochemical processes as a component of the antioxidant superoxide dismutase and protects the testicular endothelium and sperm cell membranes Zn exists at high levels in the testis of vertebrates which are comparable to liver and kidney.

Moreover, there are certain reports that manifest Zn can reduce testis injury by stresses such as heavy metals, fluoride, and heat Zn is assembled in the testis during early spermatogenesis and may play a main role in the adjustment of the spermatogonial reproduction and in the meiosis of germ cells Mostly, Zn assembles in germ cells and its concentration in testis increments during spermatogenesis.

Some researchers have witnessed that Zn is needed for the normal functioning of the hypothalamus-pituitary-gonadal axis. Because of the important role of Zn in male reproductive potential, it is paramount to recognize that andrological variations which are most sensitive to Zn depletion. An evaluation of those variables in clinical cases of possible Zn deficiency would accelerate treatment. Zn influences male fertility in several different ways. Low Zn levels have a negative effect on serum testosterone concentration Thyroid hormones have several important roles in the body including metabolism, development and even body temperature.

Zn helps the body maintain proper thyroid function by producing hormones in the brain called thyroid-releasing hormones. Whenever men are low in Zn, they may fail to produce enough of these hormones.

That can also affect testosterone levels 4. Seminal Zn is considered as an indicator of prostatic function; however, the function of Zn in seminal plasma and semen is unknown.

Most Zn "Zinc and sperm motility" from the prostate in humans seems to target the proteins secreted from seminal vesicle.

Other research Zinc and sperm motility that the Zn and albumin secreted from the prostate constitute a complex that covers the sperm and thereby protects the cells Zn is situated primarily in the Leydig cells, the late type B spermatogonia, and the spermatids.

And also is vital for the production and secretion of testosterone from the Leydig cells. Zn in human semen seems to play an important role in the physiology of spermatozoa. On the other hand, there is remarkable evidence that Zn deficiency causes primary testicular failure, lessens function of the luteinizing hormone receptor, lessens steroid synthesis and Leydig cell damage due to oxidative stress The prostate compared to other tissues and body fluids has high concentration of Zn.

Actually, Zn is a marker of prostatic function. Its other roles are regulation of the functions of spermatozoa, acting as a co-factor for most enzymatic reactions, and helping in preservation of sperm motility Zn as a downward molecular weight complex with citrate or bound to glycoproteins of the sperm vesicles is discharged from the prostate demonstrating that biologic Zn therapy has a positive effect on sperm motility and the use of biologic Zn supplementation was an efficient method for the treatment of infertile males with chronic prostatitis Zn oxide nanoparticles have bactericidal effects on both gram-positive and gram-negative bacteria and are also effective against spores which are resistant to high temperature and high pressure 28 Zinc and sperm motility Zn may have antibacterial activity because trichomonas vaginalis is easily killed at concentrations of Zn that occur in the prostatic fluid of healthy men Furthermore, Zn has antibacterial activity and antilipid peroxidation properties that maintain sperm membrane stability and protect the testis against the degenerative changes Evidence suggests that seminal Zn Zinc and sperm motility an important role in the physiologic functions of the sperm and that its reduced levels result in low seminal quality and subsequent chances of fertilization 6.

Zn is known to be essential for sexual maturity and onset of estrus.

Zinc supplementation was found to...

Zn plays a role in epithelial integrity, showing that Zn is essential for maintaining the lining of the reproductive organs 6. Furthermore, it has an important role in stabilizing the cell membrane and nuclear chromatin of spermatozoa in seminal plasma. It may have a regulative role in the progress of capacitation and acrosome reaction.

Int J Androl. Jun;15(3) Effect...

The Zn concentration in human seminal plasma is higher than in other tissues Zn has been shown to be vital for spermatogenesis. It plays a significant role in testis development and sperm physiologic functions 6. Zn contains a variety of roles in the spermatogenesis phases Table 4. For example, in the initiation of spermatogenesis, Zn is important in participation of ribonuclease activities that is highly active during mitosis of spermatogonia and meiosis of spermatocytes.

During spermatogenesis, spermatids obtain tail and motility with a developed mid-piece which connects the head compartment with the tail. This physical maturation process occurs in seminiferous tubule. Sperm maturation and storage happens in the epididymis. At the end of spermatogenesis, Zn is highly concentrated in the tail of mature spermatozoa and involved in sperm motility Though the dynamics of Zn during sperm expansion is far to be ambiguous but, the significant role of Zn in normal spermatogenesis and sperm suitability is known.

Optimal concentrations of Zn in the seminal plasma have also been related to an increase in sperm concentration of the ejaculate 11high motility, viability 32 and enhancing antioxidant activity Zinc and sperm motility low concentration of Zn has been indicated to disturb the fatty acid composition of the testis and interfere Zinc and sperm motility normal endocrine regulation Zinc and sperm motility the testis Zn is associated with catabolism of lipid that is done in sperm middle piece and provides energy for motion of spermatozoa.

Testicular Zn is crucial for normal spermatogenesis and for sperm physiology; it maintains genomic integrity in the sperm and fixes attachment of sperm head to tail Zn ions can increase male fertility by regulation of the expression of testis GC-specific genes during the differentiation process and spermatogenesis 35"Zinc and sperm motility" Also Zn therapy reduced asthenozoospermia Supra-nutritional doses of Zn, Co, and Se were used to enhance the production of motile sperm with intact membranes The negative correlation between seminal plasma Zn and sperm viability is a good sign of the importance of Zn in spermatogenesis This may be clarified by the necessary role of Zn in protein metabolism and nucleic acid synthesis.

Alteration of seminal plasma Zn changes count, motility, viability, pH and viscosity.

Introduction

Seminal plasma Zn-T Zn per ejaculate is the better marker for assessing the relationship between Zinc and sperm motility and semen quality Low seminal Zn levels have been related with decreased fertility potential. However, other authors reported that normozoospermic and oligoasthenozoospermic patients had similar seminal plasma Zn concentrations There is extensive evidence that human seminal Zn has an important role in the physiologic sperm functions and Zn reduced levels led to low quality of sperm and reduced fertilization chances.

Some authors have reported that high Zn concentration are correlated with enhanced sperm parameters, including sperm count, motility, and normal morphology 111242whereas in Danscher et al. Zhao and Xiong observed a lower content of Zn in the seminal plasma of infertile subjects and a positive relationship with poor sperm production and poor sperm motility Many studies could not find a significant dependence between total Zn in seminal plasma and sperm quality 17 Hosseinzadeh Colgar et al.

Int J Androl. Jun;15(3) Effect of zinc on human sperm motility and the acrosome reaction. Riffo M(1), Leiva S, Astudillo J. Author information. Zinc as a hormone balancer helps hormones such as testosterone, prostate and .

s study, a high concentration Zinc and sperm motility Zn is correlated with poor sperm motility (43). Zinc has been shown to play a role in regulating sperm count and quality. Men who are infertile tend to have lower zinc levels than men who.


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Effect of zinc on human...

Zhao and Xiong observed a lower content of Zn in the seminal plasma of infertile subjects and a positive relationship with poor sperm production and poor sperm motility It is notable that both zinc Huang et al. Quantitative meta-analysis was performed by two reviewers using Review Manager RevMan software version 5. Semenogelin, the main protein of the human semen coagulum, regulates sperm function. Vitamin B is a critical nutrient to overall sperm health.

This article lists some of the main lifestyle factors, foods, nutrients and supplements that have been associated with improved fertility in men. Excessive drinking can have a negative impact on sperm production and quality.

Our investigation showed that Zn contained multifold unique properties in human, especially males. The antioxidant grade is one of them. Also, the increased reactive oxygen species levels in the seminal plasma of men who are both infecund and smokers move the Zn contented of seminal plasma in a progressing that physiology of spermatozoa can be affected as agreeably.

Moreover, Zn acts as a toxic repercussionagainst heavy metals and cigarette treacherous agents. It plays a role in epithelial integrity, showing that Zn is essential for maintaining the lining of the reproductive organs and may bring into the world a regulative place in the extension of capacitation and acrosome reaction.

In contrast, Zn scantiness impedes spermatogenesis and is a object for sperm abnormalities and has a negative effect on serum testosterone concentration.

Based on these findings, Zn microelement is very fundamental for male fertility. It could be considered as a nutrient marker with many potentials in prevention, diagnosis, and treatment of spear infertility.

Sexual supplemental glands secrete in the seminal plasma containing some elements that protect spermatozoa at the dead for now of ejaculation 1. Zn is a plentiful microelement in the body and it is plant in nuts, legumes 3 , seafood e. Oysters Sui generis, fortified cereals, cremini mushrooms, low-fat yogurt 4 and sensual proteins, such as meat, fish and milk. Some reports showed that consumption of these ordinary foods can swell germinal cell build-up 5 , and poor Zn nutrition may be an important risk middleman for the ineffective quality of sperm and idiopathic man's infertility 6.

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My work colleague seems genuinely scared of me. What's going on? Int J Androl. Jun;15(3) Effect of zinc on human sperm motility and the acrosome reaction. Riffo M(1), Leiva S, Astudillo J. Author information. Objective: To measure the zinc content of human sperm flagella and to analyze its relation to sperm motility. Design: Prospective study. Setting: Center of..

  • EFFECT OF ZINC ON HUMAN SPERM MOTILITY AND THE ACROSOME REACTION.
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It affects about a specific in every six couples, and researchers estimate about anybody in every three cases is merited to fertility scrapes in the spear partner alone 1 , 2. While infertility is not always treatable, it can sometimes be improved with a healthy diet, supplements and other lifestyle strategies. This exposition lists some of the main lifestyle factors, foods, nutrients and supplements that have been associated with improved fertility in men.

Manful infertility is when a man has a poor lucky of making his female partner eloquent. It usually depends on the eminence of his sperm cells. Infertility can have multiple causes and may depend on genetics, extended health, fitness, diseases and dietary contaminants.

Additionally, a shape lifestyle and regime are important. Some foods and nutrients are associated with greater fertility benefits than others. D-aspartic acid D-AA is a form of aspartic acid, a type of amino acid that's sold as a dietary supplement.

It should not be at sea with L-aspartic acid, which makes up the structure of many proteins and is far more common than D-AA. D-AA is large present in determined glands, such as the testicles, as well as in semen and sperm cells. Researchers find credible that D-AA is implicated in manful fertility.

In the poop indeed, D-AA levels are significantly lower in infertile men than fertile men 3. This is supported by studies showing that D-AA supplements may increase levels of testosterone, the male sex hormone that plays an essential role in male fertility.

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Zinc and sperm motility
  • Int J Androl. Jun;15(3) Effect of zinc on human sperm motility and the acrosome reaction. Riffo...
  • Zinc as a hormone balancer helps hormones such as testosterone, prostate and...
  • Objective: To measure the zinc content of human sperm flagella and to...

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