Sexual dysfunctions are associated with multiple medical and psychiatric disorders, as well as pharmacotherapies used to treat these disorders. Although sexual dysfunctions negatively affect both quality of life and treatment adherence,
Alprazolam Sexual Side Effects infrequently volunteer these symptoms and clinicians do not pose directed questions to determine their presence or severity. This issue is especially important in psychiatric patients, for whom most common psychotropics may cause sexual dysfunctions antidepressants, antipsychotics, anxiolytics and mood-stabilising agents.
There is limited literature addressing benzodiazepines, and alprazolam in particular. A year-old male psychiatric patient presented with new-onset anorgasmia in the context of asymptomatic generalised anxiety disorder, social anxiety, panic disorder with agoraphobia, obsessive—compulsive disorder, major depression in remission, and attention-deficit hyperactivity disorder Alprazolam Sexual Side Effects with escitalopram 10 mg q.
The patient denied any sexual dysfunction with alprazolam at 1 mg q. Within 1 week of increasing alprazolam to 2. Anorgasmia was alprazolam dose-dependent, as anorgasmia resolved with reduced weekend dosing 1 mg b. Sexual dysfunction is an important adverse effect negatively influencing therapeutic outcome.
This case reports alprazolam-induced dose-dependent anorgasmia. Routine sexual histories are indicated. Sexual dysfunction adverse effects, including delayed orgasmic activity, have Alprazolam Sexual Side Effects reported with different benzodiazepines with varying frequency and selectivity.
To better appreciate the importance of anorgasmia with alprazolam, its role in treatment nonadherence and patient-oriented dosing strategies, this case report describes alprazolam-induced dose-dependent anorgasmia.
Medical conditions included elevated transaminases, obesity body mass index A right upper quadrant abdominal ultrasound revealed fatty liver changes.
His medical conditions were stable the time period of alprazolam titrations. Within 1 week of increasing alprazolam ER to 2. He reviewed all aspects of sexual functioning and recognised that at alprazolam ER 1.
Further, following the week period described, the patient experimented with taking weekday alprazolam ER 2—2. This unique case presents important steps in determining the aetiology of this patient's sexual dysfunction decreased orgasmic activity and subsequent anorgasmia in the context of multiple psychiatric diagnoses, medical comorbidities and psychotropic interventions. First, each of the patient's psychiatric diagnoses were associated with sexual dysfunctions — major depressive disorder, obsessive—compulsive disorder, generalised anxiety disorder, social anxiety, panic disorder and attention-deficit hyperactivity disorder.
Second, both GERD and obesity are associated with increased sexual dysfunction. Fourth, the patient described normal sexual function with stable medical and psychiatric diagnoses and baseline psychotropics.
Fifth, when considering the onset of decreased orgasmic activity and anorgasmia, only two events had occurred — increased anxiety that had necessitated, and was responsive to, increased alprazolam.
Alprazolam-induced anorgasmia has no well-defined mechanism of action in humans. In this case, only escitalopram was a weak CYP3A inhibitor; it has been suggested that at therapeutic dosage there should be no clinically significant effect on alprazolam. In the third instance, alprazolam, similar to other benzodiazepines, is a positive allosteric modulator of the gamma-amino butyric acid GABA -A receptor. Key strengths in this case report include that: Limitations in this case report include that: ASEX was used; and f no hormone levels were obtained.
Finally, for ethical reasons, the patient could not be requested to repeat the relative nonadherence with further testing to verify the current findings. The potential clinical implications of this report can best be appreciated in the context of anxiety disorder prevalence and alprazolam prescription patterns.
Specifically, the National Comorbidity Survey Replication NCS-R study, 35 using retrospective ascertainment, reported that anxiety disorders have a Alprazolam is the most frequently prescribed benzodiazepine and the third most frequently prescribed psychotropic in the USA 5. To address this problem, large-scale studies are required, as are routine sexual histories, and further education for clinicians and patients.
Sexual dysfunction is an important psychosocial comorbidity affecting QoL and treatment adherence. This case described dose-dependent alprazolam-induced anorgasmia in the context of multiple psychotropics, psychiatric diagnoses, and medical diagnoses. Routine sexual histories are necessary to ascertain the presence of sexual dysfunctions, avoid nonadherence, and to maximise treatment outcomes. Further education regarding alprazolam-induced sexual dysfunction is indicated for both clinicians and patients.
National Center for Biotechnology InformationU. Published online Jul Find articles by Rehan Aziz. Author information Article notes Copyright and License information Disclaimer.
The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. Abstract Background Sexual dysfunctions are associated with multiple medical and psychiatric disorders, as well as pharmacotherapies used to treat these disorders.
Aims To report dose-dependent alprazolam anorgasmia. Method Case analysis with PubMed Alprazolam Sexual Side Effects review. Results A year-old male psychiatric patient presented with new-onset anorgasmia in the context of asymptomatic generalised anxiety disorder, social anxiety, panic disorder with agoraphobia, obsessive—compulsive disorder, major depression in remission, and attention-deficit hyperactivity disorder treated with escitalopram 10 mg q.
Conclusions Sexual dysfunction is an important adverse effect negatively influencing therapeutic outcome. Declaration of interest None. Alprazolam, benzodiazepine, sexual dysfunction, anorgasmia, adverse effect, nonadherence, anxiety disorder, major depressive disorder, obsessive—compulsive disorder, attention-deficit hyperactivity disorder, clinical care, education.
Discussion This unique case presents important steps in determining the aetiology of this patient's sexual dysfunction decreased orgasmic activity and subsequent anorgasmia in the context of multiple psychiatric diagnoses, medical comorbidities and psychotropic interventions.
Conclusion Sexual dysfunction is an important psychosocial comorbidity affecting QoL and treatment adherence. Risk factors for sexual dysfunction among women and men: J Sex Med ; The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management.
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have been some reports that anti-anxiety drugs like Xanax can lower your sex drive. Alprazolam Side Effects
Alprazolam Sexual Side Effects Likelihood and Severity Altered Interest In Having Sexual Intercourse; Depression; Drowsiness; Inducing Of A Relaxed Easy State. Alprazolam/adverse effects*; Alprazolam/pharmacology; Female; Humans; Libido /drug effects*; Male; Penile Erection/drug effects*; Sexual Behavior/drug effects.